1619 - North America, northern east coast - Small pox (Native Americans)
1633 North eastern North America - Small pox
1657  Boston, Massachusetts - Measles
1677-8 Boston Massachusetts - Small pox (1/5th of town dead)
1687  Boston, Massachusetts - Measles
1690  New York City, New York - Yellow Fever
1692 Boston, Massachusetts - Small pox
1699 Philadelphia PA, Charleston - Yellow fever
1702-1703 St. Lawrence Valley, NY - Small pox
1713  Boston, Massachusetts - Measles
1721 Boston, Massachusetts - Small pox
1729  Boston, Massachusetts - Measles
1732-3 Worldwide - Influenza
1735 New England - Scarlet fever
1735-40 New England - Diptheria
1736 Pennsylvania - Small pox
1738  South Carolina - Small pox
1739-40  Boston, Massachusetts - Measles
1747  CT, NY, PA, SC - Measles
1759 North America - Measles
1761 North America and West Indies - Influenza
1764  Boston, Massachusetts - Small pox
1769 Massachusetts - Scarlet fever
1770's West coast of North America - Small pox wipes out 30% of Native Americans
1772 North America - Measles
1775 North America (especially New England) Unknown epidemic
1774-6 Worldwide - Influenza
1781-3 Great Lakes - Small pox
1783 Dover, Delaware Bilious Disorder ("Extremely fatal")
1787 Maine - Scarlet fever
1788 Philadelphia, PA and New York - Measles
1793 Vermont - "putrid fever" and Influenza
         Virginia - Influenza (500 dead in 5 counties in 4 weeks)
         Harrisburg, PA - Unknown epidemic with many deaths
         Middletown, PA - Unknown epidemic with many deaths
         Philadelphia, PA - Yellow fever
1794 Philadelphia, PA - Yellow fever
1795 New York - Yellow fever
1796-7 Philadelphia, PA - Yellow fever
1798 Philadelphia, PA - Yellow fever
1803 New York - Yellow fever
1820 Wisconsin - Measles (Native American settlements)
1820-3 North America - "fever"
1831-2 North America - Asiatic Cholera (brought by English emigrants)
1832 New York City and other major cities - Cholera
1833 Columbus, Ohio - Cholera
1834 - New York City - Cholera
1837 Philadelphia - Typhus
1841 North America - Yellow fever (worst in the South)
1847 New Orleans - Yellow fever
1847-8 Worldwide - Influenza
1848-9 North America - Cholera
1849 New York City - Cholera
1850 North America - Yellow fever
1850-1 North America - Influenza
1851 Coles Co., IL, the Great Plains, Missouri - Cholera
1852 North America - Yellow fever (8,000 dead in New Orleans that summer)
1855 North America - Yellow fever
1857-9 Worldwide - Influenza
1860-1 Pennsylvania - Small pox
1861-2 Richmond, VA - Scarlet fever
1861-1865 - North America - Typhoid (187,000 dead)
1862 Florida - Scarlet fever
1863 New Orleans - Yellow fever
1863 Minnesota - Scarlet fever
1865-73 Philadelphia, NY, Boston, New Orleans - Small pox
             Washington D.C., Baltimore, Memphis - Cholera and a series of recurring epidemics of Thyphus, Scarlet fever, Yellow fever
1873-5 North America and Europe - Influenza
1873  Nebraska - Diptheria
1877 Los Angeles, CA - Small pox
1878 New Orleans, Memphis - Yellow fever (last great epidemic)
1885 Plymouth, PA - Typhoid
1886  Jacksonville, FL - Yellow fever
1890 - Waterbury, CT - Typhoid
1890-2 Chicago - Typhoid
1899 Harrisburg, PA - Typhoid
1900  San Francisco - Bubonic plague
1902-3 Maine - Typhoid
1903  Connecticut - Scarlet fever
          Ithaca, NY - Typhoid
1905 Charlottesville, VA - Scarlet fever
1915 New York - Typhoid
1916  North America - Polio
         Illinois - Typhoid
1918 - Worldwide - Influenza