Alexander Holmes was born about 1770 in Dublin, Ireland.  He married Jane McCaw about 1792 in Ireland.  Jane McCaw was born about 1772 in Dublin.  Born to them were David Holmes, John McCaw Holmes, Margaret, Jane, Rhoda, Mary G., Castria, William, Telemachus, Angeline, Horatio Nelson  Viscount and Foster.  Alexander , the father, was a school teacher in Virginia and Kentucky.

David Holmes, the oldest son, was killed in a barn raising in Pulaski Co., Ken in 1817.  He was about 22 years old. Margaret never married and lived with her brother, Telemachus who also never married.   Jane Holmes  Ingram died giving birth to a daughter who also died about 1820.  She was around 20 years old. After Castria's marriage to Samuel Sly, it is unknown what happened to her.  William died as a child in Wythe Co.,  Va.  Angeline did not marry. 

John McCaw Holmes was born 4 Oct 1795 in Wythe Co., Va. He married Jerusha Hill 6 Aug 1827 in Pulaski Co., Kentucky. Jerusha, born 7 Dec 1808 in Kentucky,  was the daughter of John and Delilah Cooper Hill.  Children of John and Jerusha were: David (1828-); Polly Ann (1829-1863); William A.T.(1832-1900); Amanda J.(1835-1896); John H. (1837-1864); Theodore Foster(1840-1904); James G. (1842-1855); Telemachus P.(1845-); Horatio Dallas(1845-1903).

Rhoda married Silas Lee 15 Nov 1826 in Pulaski Co., Kentucky.  She and eight of her eleven children died in a cholera epidemic in New Madrid, MO between 1840 and 1850.  Known children of the couple were: Faunt, Rhodett, Silas B., and Amanda.  Frederick Lee, listed with the family in one census shows a birthplace of Germany.  Elsewhere his birthplace is listed as Missouri.

Horatio Nelson Viscount Holmes married Nancy Porter 27 Sep 1837 in Pike Co., IL.  Their children were David J., Nancy Jane, Alexander M., John Porter, William Henry, Horatio R., and Mary Adele.  This family immigrated to Polk Co., Oregon in 1848 and was instrumental in establishing the early Oregon government.