Lizzy's husband was William James. He was son of Beverly W. James and Matilda (Day) and was born on 04 Oct 1822 in Mason Co., Kentucky. He married his first wife, Sarah or "Sallie" Mayberry in 1851 and had by her five children, the first having died in infancy in 1852, and the four surviving being Lora, Luella, Belle, and William James.

After his wife Sallie passed away in 1867, he and his children temporarily lived with his mother and on 13 March 1872, he married Lizzy. A short nine months later, William James died and Lizzy returned to live with her mother.

Lizzy Daily-James was the mother of one son, Jimmy James. In 1900 she was listed as head of household, and her household included her son James as well as her sister Louisa, nephew Frank S. Daily amd a retired lodgers. She died on 14 April 1925 in Charlestown and was laid to rest in the Charlestown Cemetery.