In 1828, Rev. Case was appointed general Superintendent of the church, and Superintendent of Indian Missions. Henceforth he devoted more of his time to Indian work, and after 1833 his entire time. As a result he gradually faded from the limelight. He located himself at different Mission stations, and died in 1855 at Alderville mission (just north of Cobourg), named after Rev. Robert Alder D.D., one of the leaders of the Wesleyan Church.