Ralls County was formed, 1821 from Pike County and was named after Daniel Ralls, Missouri legislator.
Ralls is bounded by Pike, Audrain, Monroe, & Marion Counties, and the Mississippi River. Ralls is very much a rural county, the 1990 Census showing a population of 8,476. The county seat is New London, Missouri. The town of Hannibal straddles Ralls County & Marion County; location of the Mark Twain Memorial Bridge, and the boyhood home of "Mark Twain". A little further north, and then east across the Mississippi River, and you will be in Quincy, Illinois, the largest metropolis of the area.