Observed Mutation Rates As Reported By YHRD

Observed Mutation Rates As Reported By YHRD

Locus DYS19

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		996	2	2.01	Kayser et al. 2000
		249	0	n.a.	Bianchi et al. 1998
		213	0	n.a.	Heyer et al. 1997
		161	0	n.a.	Kurihara et al. 2004
		1766	3	1.70	Dupuy et al. 2004
		245	1	4.08	Ballard et al. 2005
		692	2	2.89	Budowle et al. 2005
		2807	4	1.42	Gusmao et al. 2005
Total		7129	12	1.68 (0.87-2.94 95% CI)


	Locus DYS389i

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		425	1	2.35	Kayser et al. 2000
		249	0	n.a.	Bianchi et al. 1998
		161	1	6.21	Kurihara et al. 2004
		1766	4	2.26	Dupuy et al. 2004
		247	1	4.05	Ballard et al. 2005
		692	1	1.44	Budowle et al. 2005
		1793	2	1.11	Gusmao et al. 2005
Total		5333	10	1.87 (0.97-3.46 95% CI)


	Locus DYS389ii

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		249	0	n.a.	Bianchi et al. 1998
		425	2	4.71	Kayser et al. 2000
		161	1	6.21	Kurihara et al. 2004
		1766	4	2.26	Dupuy et al. 2004
		246	2	8.13	Ballard et al. 2005
		692	1	1.44	Budowle et al. 2005
		1781	2	1.12	Gusmao et al. 2005
Total		5320	12	2.26 (1.17-3.94 95% CI)


	Locus DYS390

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		466	4	8.58	Kayser et al. 2000
		249	0	n.a.	Bianchi et al. 1998
		213	0	n.a.	Heyer et al. 1997
		161	0	n.a.	Kurihara et al. 2004
		1766	8	4.53	Dupuy et al. 2004
		248	0	n.a.	Ballard et al. 2005
		692	0	n.a.	Budowle et al. 2005
		2816	3	1.06	Gusmao et al. 2005
Total		6611	15	2.27 (1.27-3.74 95% CI)


	Locus DYS391

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		415	2	4.82	Kayser et al. 2000
		249	0	n.a.	Bianchi et al. 1998
		213	0	n.a.	Heyer et al. 1997
		161	1	6.21	Kurihara et al. 2004
		1766	8	4.53	Dupuy et al. 2004
		248	2	8.06	Ballard et al. 2005
		692	1	1.44	Budowle et al. 2005
		2815	9	3.20	Gusmao et al. 2005
Total		6559	23	3.51 (2.22-5.26 95% CI)


	Locus DYS392

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		415	0	n.a.	Kayser et al. 2000
		249	0	n.a.	Bianchi et al. 1998
		213	1	4.69	Heyer et al. 1997
		161	0	n.a.	Kurihara et al. 2004
		1766	0	n.a.	Dupuy et al. 2004
		226	0	n.a.	Ballard et al. 2005
		692	0	n.a.	Budowle et al. 2005
		2803	3	1.07	Gusmao et al. 2005
Total		6525	4	0.61 (0.17-1.57 95% CI)


	Locus DYS393

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		415	0	n.a.	Kayser et al. 2000
		249	0	n.a.	Bianchi et al. 1998
		213	0	n.a.	Heyer et al. 1997
		161	0	n.a.	Kurihara et al. 2004
		1766	1	0.57	Dupuy et al. 2004
		248	0	n.a.	Ballard et al. 2005
		692	1	1.44	Budowle et al. 2005
		1569	2	1.27	Gusmao et al. 2005
Total		5313	4	0.75 (0.21-1.93 95% CI)


	Locus DYS385a,b

		No. of meioses¹	No. of mutations	Mutation rate (x10-3)	Reference
		952	2	2.10	Kayser et al. 2000
		426	1	2.35	Heyer et al. 1997
		322	0	n.a.	Kurihara et al. 2004
		3532	7	1.98	Dupuy et al. 2004
		472	4	8.47	Ballard et al. 2005
		1384	3	2.17	Budowle et al. 2005
		2749	5	1.82	Gusmao et al. 2005
Total		9837	22	2.24 (1.40-3.38 95% CI)


	Locus DYS438

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		161	0	n.a.	Kurihara et al. 2004
		225	0	n.a.	Ballard et al. 2005
		692	0	n.a.	Budowle et al. 2005
		1213	1	0.82	Gusmao et al. 2005
Total		2291	1	0.44 (0.01-2.47 95% CI)


	Locus DYS439

		No. of meioses	No. of mutations	Mutation rate (x10-3)	Reference
		161	1	6.21	Kurihara et al. 2004
		249	1	4.02	Ballard et al. 2005
		692	2	2.89	Budowle et al. 2005
		1164	8	6.87	Gusmao et al. 2005
Total		2266	12	5.30 (2.74-9.23 95% CI)

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