More about mutation rates, individual markers and ancestral haplotypes
1.Clan MacLeod Project Overview / 2. Clan MacLeod Project Modal Haplotype (Hypothetical) / 3. Ancestral Modal Haplotypes /
4. Understanding the Markers and Mutation Rates / 5. Our Participants Results / 6. A Closer Look at our matches / 7. Current Conclusions
NEW PAGES : Full Result Table / Sub Group B Results Table / Branching Table / LCF Rates Table / Frequently Asked Questions / Mutation Rates
FTDNA uses a standard rate of .0040 for the markers, while other companies use .002 - the surname projects seem to substantiate FTDNA's rate. Kerchner's webpage has a good discussion of this using his own project's mutation rates. Interestingly, he also discusses the mutation rates for haplotypes as well as individual markers. The number of generations that a haplotype can survive unchanged could be of great importance to our MacLeod project in that we have toggling alleles at DYS 389i & ii and DYS 459b.
The table below shows the four 67 marker haplotypes that appear to be the most common among known families and suspected branches in the project as of today. These haplotypes represent the toggling that is occurring among the kits shown as related to one another and to the project haplotype (currently #1 in the table). For haplotypes, a slightly higher rate is used by FTDNA.
| FTDNA Configuration - DNA Results Comparison - YUtility | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ID |
D Y S 3 9 3 |
D Y S 3 9 0 |
D Y S 1 9 / 3 9 4 |
D Y S 3 9 1 |
D Y S 3 8 5 a |
D Y S 3 8 5 b |
D Y S 4 2 6 |
D Y S 3 8 8 |
D Y S 4 3 9 |
D Y S 3 8 9 - 1 |
D Y S 3 9 2 |
D Y S 3 8 9 - 2 |
D Y S 4 5 8 |
D Y S 4 5 9 a |
D Y S 4 5 9 b |
D Y S 4 5 5 |
D Y S 4 5 4 |
D Y S 4 4 7 |
D Y S 4 3 7 |
D Y S 4 4 8 |
D Y S 4 4 9 |
D Y S 4 6 4 a |
D Y S 4 6 4 b |
D Y S 4 6 4 c |
D Y S 4 6 4 d |
D Y S 4 6 0 |
G A T A H 4 |
Y C A I I a |
Y C A I I b |
D Y S 4 5 6 |
D Y S 6 0 7 |
D Y S 5 7 6 |
D Y S 5 7 0 |
C D Y a |
C D Y b |
D Y S 4 4 2 |
D Y S 4 3 8 |
D Y S 5 3 1 |
D Y S 5 7 8 |
D Y S 3 9 5 S 1 a |
D Y S 3 9 5 S 1 b |
D Y S 5 9 0 |
D Y S 5 3 7 |
D Y S 6 4 1 |
D Y S 4 7 2 |
D Y S 4 0 6 S 1 |
D Y S 5 1 1 |
D Y S 4 2 5 |
D Y S 4 1 3 a |
D Y S 4 1 3 b |
D Y S 5 5 7 |
D Y S 5 9 4 |
D Y S 4 3 6 |
D Y S 4 9 0 |
D Y S 5 3 4 |
D Y S 4 5 0 |
D Y S 4 4 4 |
D Y S 4 8 1 |
D Y S 5 2 0 |
D Y S 4 4 6 |
D Y S 6 1 7 |
D Y S 5 6 8 |
D Y S 4 8 7 |
D Y S 5 7 2 |
D Y S 6 4 0 |
D Y S 4 9 2 |
D Y S 5 6 5 |
| 1 | 13 | 25 | 14 | 11 | 11 | 14 | 12 | 12 | 12 | 13 | 13 | 29 | 16 | 9 | 10 | 11 | 11 | 26 | 15 | 19 | 31 | 14 | 15 | 15 | 16 | 11 | 11 | 19 | 23 | 16 | 15 | 18 | 17 | 37 | 37 | 12 | 12 | 11 | 9 | 15 | 16 | 8 | 10 | 10 | 8 | 10 | 10 | 12 | 23 | 23 | 16 | 10 | 12 | 12 | 16 | 8 | 12 | 22 | 20 | 15 | 12 | 11 | 13 | 11 | 11 | 12 | 12 |
| 2 | 13 | 25 | 14 | 11 | 11 | 14 | 12 | 12 | 12 | 14 | 13 | 30 | 16 | 9 | 11 | 11 | 11 | 26 | 15 | 19 | 31 | 14 | 15 | 15 | 16 | 11 | 11 | 19 | 23 | 16 | 15 | 18 | 17 | 37 | 37 | 12 | 12 | 11 | 9 | 15 | 16 | 8 | 10 | 10 | 8 | 10 | 10 | 12 | 23 | 23 | 16 | 10 | 12 | 12 | 16 | 8 | 12 | 22 | 20 | 15 | 12 | 11 | 13 | 11 | 11 | 12 | 12 |
| 3 | 13 | 25 | 14 | 11 | 11 | 14 | 12 | 12 | 12 | 14 | 13 | 30 | 16 | 9 | 10 | 11 | 11 | 26 | 15 | 19 | 31 | 14 | 15 | 15 | 16 | 11 | 11 | 19 | 23 | 16 | 15 | 18 | 17 | 37 | 37 | 12 | 12 | 11 | 9 | 15 | 16 | 8 | 10 | 10 | 8 | 10 | 10 | 12 | 23 | 23 | 16 | 10 | 12 | 12 | 16 | 8 | 12 | 22 | 20 | 15 | 12 | 11 | 13 | 11 | 11 | 12 | 12 |
| 4 | 13 | 25 | 14 | 11 | 11 | 14 | 12 | 12 | 12 | 13 | 13 | 29 | 16 | 9 | 11 | 11 | 11 | 26 | 15 | 19 | 31 | 14 | 15 | 15 | 16 | 11 | 11 | 19 | 23 | 16 | 15 | 18 | 17 | 37 | 37 | 12 | 12 | 11 | 9 | 15 | 16 | 8 | 10 | 10 | 8 | 10 | 10 | 12 | 23 | 23 | 16 | 10 | 12 | 12 | 16 | 8 | 12 | 22 | 20 | 15 | 12 | 11 | 13 | 11 | 11 | 12 | 12 |
This second table shows the TMRCA for the four haplotypes as calculated by YUtility - italics/red font mine
|
Time
to Most Recent Common Ancestor (Years)
|
| ID | 1 | 2 | 3 | 4 |
| 1 | - | 360 (cr. 1649) | 300 (cr. 1709) | 300 (cr. 1709) |
| 2 | 360 (cr. 1649) | - | 300 (cr. 1709) | 300 (cr. 1709) |
| 3 | 300 (cr. 1709) | 300 (cr. 1709) | - | 360 (cr. 1649) |
| 4 | 300 (cr. 1709) | 300 (cr. 1709) | 360 (cr. 1649) | - |
|
- Infinite
allele mutation model is used |
Due to the toggling at DYS 389 and DYS 459b, matches on these markers should be viewed as convergence (random mutation to the same allele) unless other factors exist to indicate a more recent branching than that indicated by the TRMCA predictions above.
The following information uses a rate of .002 which was the standard in the early years of Genetic DNA testing as compared to Kerchner's Project rate which varies from testing level to testing level. The MacLeod project indicates that the Clan's mutation rate varies from branch to branch and so falls somewhere in between the two rates.
Y-STR (37) haplotype
mutation rate
A new mutation can happen at any time but a 37 marker haplotype using the .002
historical rate indicates it can typically survive unchanged since the generation
of the prior mutation event for a bit more than a dozen generations (approximately
360 years). Random matches are minimal. Random matches in the MacLeod Project
using the current project haplotype = 1 at 37 - 1 (a MacKenzie); 1 at 37 - 2
(a Gallie); 3 at 37 - 3 (a Ross, a MacQueen, a Helton)
Kerchner
Surname
Project
the
37
marker
average
haplotype
mutation
rate
for
ten
people
YDNA37
tested
is
.0057.
The
37
Kerchner
haplotype
on
average
can
typically
survive
unchanged
about
4.7
generations
(approximately
141
years)
.
Random
matches
are
minimal.
Random
matches
in
the
MacLeod
Project
using
the
current
project
haplotype
=
1
at
37
-
1
(a
MacKenzie);
1
at
37
-
2
(a
Gallie);
3
at
37
-
3
(a
Ross,
a
MacQueen,
a
Helton)
Y-STR (67)
haplotype mutation rate
A new mutation can happen at any time but a 67 marker haplotype using the .002
historical rate indicates it can typically survive unchanged since the generation
of the prior mutation event for a bit more than seven generations (approximately
210 years). Random matches will be minimal, if any. Random matches in the MacLeod
Project using the current project haplotype = 67 - 3 (Ross); 67 - 6 (McKinney)
Kerchner Surname Project the 67 marker average haplotype mutation rate for the seven people YDNA67 marker tested is .0043. The 67 Kerchner haplotype on average can typically survive unchanged about 3.5 generations (approximately 105 years). Random matches unlikely. Random matches in the MacLeod Project using the current project haplotype = 67 - 3 (Ross); 67 - 6 (McKinney)
First Table - Full Results / Second Table - Related Kits / This Page - Mutation Rates
|
DYS
#
Mutation
Rate
|
Mutations
found
in
kits
that
are
within
allowable
distances
from
the
current
MacLeod
Project
Haplotype
(does not include 12 marker only kits) |
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|
|
1 mutation from the Project Allele of 13 - this kit, added June 2009, has a Unique Mutation Event among the Sub Group B Related MacLeods participants - he is a Gen 2 at 37 markers to the Sub Group B haplotype
|
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|
DYS
390
.0040 |
2 mutations from the Project Allele of 25
|
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|
DYS
19
.0040 |
5 mutations - From the Project Allele of 14 - Could be a branch indicator - YUtility predicts that the first four kits shared a CA between 1450 and 1870 a.d. - testing of cousins could find recent mutations (since MRCA) that then could be ignored in comparing these kits which would narrow the TMRCA (Kit 106635 TMRCA with other four kits = 1060 - 1300 a.d.)
|
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|
DYS
391
|
5 mutations from the Project Allele of 11
|
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|
DYS
385a
.0040 |
One mutation from the Project Allele of 11 -
|
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|
DYS
385b
.0040 |
One mutation from the Project Allele of 14 -One 12 marker only kit shares a 15 at this allele with 37219 - should this kit upgrade and remain within allowable distances at 37 and 67 markers, this would no longer be a Unique Mutation Event among the related kits.
|
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|
DYS
439
.0040 |
6 mutations from the Project Allele of 12 The testing of additional documented members of the Talisker and Arnisdale Branches of the Harris MacLeods could help to clarify this marker. At this time, it appears to have been random and independant mutation (convergence) in the Talisker and Drynoch kits.
|
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|
DYS
389i
&
ii
.0040 |
Current Project Allele is 13/29 but toggles to the 14/30 as new kits upgrade to the 67 marker level according to just which kits are upgraded June 18 2009 - This multi-copy marker is split evenly (24/24) among those who are related to the Project Haplotype and to each other at the 37 marker levels of testing. All currently identified documented descendants of Leod carry the 14/30 combination - it is unknown if there are documented descendants who carry the 13/29 combination. However, YUtility states that TMRCA for the two haplotypes was between 1649 and 1709 a.d. or within the last 10 - 12 generations (see above) with a 95% probability. The 67 marker haplotype can survive unchanged between 3.5 - 7.5 generations or approximately 105 to 210 years (also see above). The testing of cousins of all participants in the MacLeod Project could eventually reveal a mutation occurring from the 14/30 to 13/29 or the reverse within a recent generation - i.e. my family has determined the Ancestral Haplotype of our MRCA Alexander b. cr 1783 in Scotland - however, we have not yet tested descendants of Alexander's two brothers - if descendants of both of those men should carry the other combination of alleles at this marker, then we would find that Angus MacLeod, father of Alexander and his two brothers, carried that combination and a mutation occurred since the generation born cr. 1745 in one of three branches. |
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|
DYS
458
.0048 |
Project Allele of 16 -- this appears to be a significant allele among the Project - currently there are no mutations at this marker among those who are within allowable distances of the project haplotype |
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|
DYS
459a
&
b
.0048 |
Project Allele of "9/11" when all non - related kits are removed from the table - could eventually be a significant allele among the Project - this marker toggles between the '11' and "10" - YUtility states that TMRCA for the four haplotypes was between 1649 and 11709 a.d. or within the last 10 - 12 generations (see above) with a 95% probability. The 67 marker haplotype can survive unchanged between 3.5 - 7.5 generations or approximately 105 to 210 years (also see above).
Four of five documented descendants of Leod have an allele of "11" at this marker - one kit (Glendale) has an allele of "10" indicating a mutation in that line since the EKCA of the five kits - Glendale's MRCA with kit 37219 and kit 30096 was cr. 1550 - therefore, this indicates the mutation occurred in the Glendale line in the last 13 generations or approximately 410 years. Testing of documented cousins of all five kits could bring clarity to this marker. |
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|
DYS
447
0.0048 |
5 mutations from the Project Allele of 26 - this appears to be a significant allele among the Project 39 of 45 kits related to the haplotype have an allele of 26.
|
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|
DYS
449
0.0048 |
Project Allele of 31 - this appears to be a significant allele among the Project - there are 8 mutations - 2 appear to be random mutations while 6 appear to be branch indicators
|
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|
DYS
464
0.0048 |
Project Allele Combination of 14, 15, 15, 16 - appears to be significant to the Project - 8 kits have mutations however, 4 of those kits appear to be a branch.
|
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|
DYS
460
0.0075 |
1 mutation from the Project Allele of 11 -
|
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|
GATAH4
0.0075 |
4 mutations from the Project Allele of 11 -
|
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|
YCAIIa/b
0.0075 |
Project Allele of 19/23 - One mutation
|
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|
DYS
456
0.0075 |
Project Allele of 16 - 2 mutations
|
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|
DYS
607
0.0075 |
Project Allele of 15 -1 mutation
|
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|
DYS
576
0.0075 |
Project Allele of 18 - appears to be an extremely volatile marker however there are some indications of its signifying branching.
|
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|
DYS
570
0.0075 |
6 mutations from the Project Allele of 17 -
|
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|
CDYa/b
0.0075 |
Project Alleles of 37/37 - appears to be significant to the Project - however, 11 mutations have occurred from the Project modal alleles with only 2 of them appearing to corroborate earlier indications of branching - this is considered a volatile marker among many project leaders.
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|
DYS
442
0.0075 |
Project allele = 12 - 2 mutations
|
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|
DYS395S1b
|
Marker 41 Project Allele = 16 (Mutation rates not yet determined by FTDNA - calculated at .0024 until such time as they can make the determination)
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|
DYS
537
|
Marker 43 Project Allele = 10 (Mutation rates not yet determined by FTDNA - calculated at .0024 until such time as they can make the determination)
|
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|
DYS
406S1
|
Marker 46 Project Allele = 10 (Mutation rates not yet determined by FTDNA - calculated at .0024 until such time as they can make the determination)
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|
DYS
534
|
Marker 55 Project Allele = 16 - appears to be significant to the Project (Mutation rates not yet determined by FTDNA - calculated at .0024 until such time as they can make the determination)
|
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|
DYS
444
|
Marker 57 Project Allele = 12 (Mutation rates not yet determined by FTDNA - calculated at .0024 until such time as they can make the determination)
|
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|
DYS
446
|
Marker 60 Project Allele = 15 - R1b allele is 13 appears to be significant to the Project (Mutation rates not yet determined by FTDNA - calculated at .0024 until such time as they can make the determination)
|
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|
DYS
565
|
Marker 67 Project Allele = 12 (Mutation rates not yet determined by FTDNA - calculated at .0024 until such time as they can make the determination)
|
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Back to: 4. Understanding the Markers and Mutation Rates
1.Clan MacLeod Project Overview / 2. Clan MacLeod Project Modal Haplotype (Hypothetical) / 3. Ancestral Modal Haplotypes /
4. Understanding the Markers and Mutation Rates / 5. Our Participants Results / 6. A Closer Look at our matches / 7. Current Conclusions
NEW PAGES : Full Result Table / Sub Group B Results Table / Branching Table / LCF Rates Table / Frequently Asked Questions / Mutation Rates